Table 2.
Maximum percentage of inhibition of J. mollissima against local effects produced by Bothrops erythromelas and B. jararaca venoms. Percentage of inhibition was calculated as [1 – (% activity of test mean – % activity of PBS control mean)/(% activity of Ber or Bja control mean – % activity of PBS control mean)] × 100.
Activity | Dose | Inhibition (%) | |
---|---|---|---|
Bothrops erythromelas | Edematogenic∗ | 50 mg/kg | 46.41 |
Inflammatory | 100 mg/kg | 81.81 | |
Myotoxic | 200 mg/kg | 81.70 | |
| |||
Bothrops jararaca | Hemorrhagic | 200 mg/kg | 44.00 |
Edematogenic∗ | 200 mg/kg | 25.19 | |
Inflammatory | 200 mg/kg | 80.18 | |
Myotoxic | 100 mg/kg | 72.73 |
∗The edematogenic activity was calculated using the area under the curve.