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. 2016 Nov 9;6:36740. doi: 10.1038/srep36740

Figure 2. Inhibition of capsaicin-evoked TRPV1 currents by LA.

Figure 2

(A) Representative recordings demonstrating inhibition of a capsaicin-induced inward current by different concentrations of LA. Cells were held at −60 mV and the co-application of LA and capsaicin (CAP, 50 nM) was started once the capsaicin-induced inward current had reached a steady-state. (B) Concentration-dependency of LA-induced inhibition of capsaicin-evoked inward currents. Current amplitudes were normalized to those before LA application. The solid line represents a fit with the Hill equation. (C) Membrane currents of TRPV1 monitored during 500-ms long voltage ramps from −100 mV to +100 mV in presence of control solution, capsaicin or capsaicin +10 mM LA. (D) Mean relative inhibition of capsaicin-induced inward currents at −100 mV and outward currents at +100 mV by 10 mM LA. Inward currents were significantly stronger inhibited as compared to outward currents. Data are presented as mean ± S.E.M. Statistical differences are indicated by *p < 0.05.