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. 2016 Nov 9;6:36740. doi: 10.1038/srep36740

Figure 3. Inhibition of heat- and pro-algesic-evoked TRPV1 inward currents by LA.

Figure 3

(A) Representative traces of inward currents evoked by heat ramps from ~23 °C to ~43 °C in control solution (left trace), in presence of 10 mM LA (middle trace) and after 1 min washout of LA (right trace). (B) Mean inward currents of heat-evoked TRPV1 currents normalized to control currents before LA application. Data are presented as mean ± S.E.M. Statistical differences are indicated by ***p < 0.001. (C,D) Membrane currents of TRPV1 monitored during 500-ms long voltage ramps from −100 mV to +100 mV in presence of control solution and after treatment with 500 μM chloramine-T (C) or 1 μM PMA (D) before and after application 10 mM LA.