Table 2. Association between alcohol consumption, ADH1B, ALDH2, CYP2E1, MTHFR, MTRR, and MTR polymorphisms, and colorectal cancer.
| Genotype Frequency (%) | Cases (n)/Controls (n) | OR1 (95% CI)a | OR2 (95% CI)b | |
|---|---|---|---|---|
| Alcohol consumption | ||||
| Never to occasional | 200/423 | 1.00 (Reference) | 1.00 (Reference) | |
| Daily and <150 g/week | 41/88 | 1.13 (0.71–1.81) | 1.25 (0.76–2.04) | |
| Daily and ≥150 g/week | 105/170 | 1.66* (1.10–2.51) | 2.12** (1.34–3.36) | |
| P for trend | 0.002 | |||
| Energy adjusted folate intakec | ||||
| Quartile 1 | 99/187 | 1.00 (Reference) | 1.00 (Reference) | |
| Quartile 2 | 104/179 | 0.88 (0.61–1.28) | 0.89 (0.57–1.40) | |
| Quartile 3 | 84/173 | 0.91 (0.63–1.31) | 0.91 (0.55–1.49) | |
| Quartile 4 | 90/174 | 0.96 (0.67–1.38) | 0.88 (0.46–1.67) | |
| P for trend | 0.74 | |||
| Alcohol Metabolic Pathway | ||||
| ADH1B rs1229984 | ||||
| AA | 56.5 | 194/400 | 1.00 (Reference) | 1.00 (Reference) |
| AG | 36.3 | 139/257 | 1.10 (0.85–1.43) | 1.16 (0.87–1.55) |
| GG | 7.2 | 23/51 | 0.93 (0.55–1.58) | 1.05 (0.59–1.87) |
| AG + GG | 43.5 | 162/308 | 1.07 (0.84–1.38) | 1.15 (0.87–1.51) |
| ALDH2 rs671 | ||||
| GG | 65.5 | 248/464 | 1.00 (Reference) | 1.00 (Reference) |
| GA | 31.4 | 96/222 | 0.82 (0.62–1.08) | 0.88 (0.63–1.21) |
| AA | 3.1 | 12/22 | 1.02 (0.50–2.08) | 0.90 (0.42–1.95) |
| GA + AA | 34.5 | 108/244 | 0.84 (0.64–1.10) | 0.88 (0.64–1.20) |
| CYP2E1 rs3813867 | ||||
| GG | 58.1 | 214/411 | 1.00 (Reference) | 1.00 (Reference) |
| CG | 36.0 | 113/255 | 0.84 (0.63–1.12) | 0.88 (0.64–1.21) |
| CC | 5.9 | 29/42 | 1.34 (0.81–2.21) | 1.43 (0.82–2.50) |
| CG + CC | 42.0 | 142/297 | 0.92 (0.70–1.19) | 0.96 (0.72–1.29) |
| Folate Metabolic Pathway | ||||
| MTHFR rs1801133 | ||||
| CC | 36.2 | 148/256 | 1.00 (Reference) | 1.00 (Reference) |
| CT | 47.3 | 148/335 | 0.75 (0.57–1.002) | 0.66* (0.48–0.91) |
| TT | 16.5 | 60/117 | 0.89 (0.61–1.28) | 0.87 (0.58–1.30) |
| CT + TT | 63.8 | 208/452 | 0.79 (0.61–1.03) | 0.72* (0.54–0.97) |
| MTHFR rs1801131 | ||||
| AA | 63.8 | 238/452 | 1.00 (Reference) | 1.00 (Reference) |
| AC | 32.3 | 100/229 | 0.82 (0.61–1.10) | 0.80 (0.58–1.11) |
| CC | 3.8 | 18/27 | 1.27 (0.68–2.36) | 1.63 (0.82–3.22) |
| AC + CC | 36.2 | 118/256 | 0.87 (0.66–1.15) | 0.88 (0.65–1.20) |
| MTRR rs1801394 | ||||
| AA | 50.9 | 186/360 | 1.00 (Reference) | 1.00 (Reference) |
| GA | 41.2 | 133/292 | 0.88 (0.67–1.16) | 0.88 (0.66–1.19) |
| GG | 7.9 | 37/56 | 1.29 (0.82–2.04) | 1.45 (0.88–2.38) |
| GA + GG | 49.2 | 170/348 | 0.95 (0.73–1.22) | 0.97 (0.73–1.28) |
| MTR rs1805087 | ||||
| AA | 63.6 | 217/450 | 1.00 (Reference) | 1.00 (Reference) |
| GA | 32.5 | 127/230 | 1.16 (0.88–1.52) | 1.10 (0.82–1.49) |
| GG | 4.0 | 12/28 | 0.90 (0.45–1.82) | 0.87 (0.39–1.95) |
| GA + GG | 36.4 | 139/258 | 1.13 (0.86–1.48) | 1.08 (0.81–1.45) |
Based on conditional logistic regression models.
*p ≤ 0.05, **p ≤ 0.01.
aMatched for age (±3 years), sex, area, blood donation date (±2 months), and fasting time at blood donation (±5 hours).
bFurther adjusted for body mass index, family history of colorectal cancer, physical activity, energy adjusted intake of red meat, processed meat, vegetables, fruits, fish, energy adjusted intake of calcium, vitamin D, vitamin B2, vitamin B6, vitamin B12, folate, and smoking status.
cFurther adjusted for body mass index, family history of colorectal cancer, physical activity, energy adjusted intake of red meat, processed meat, vegetables, fruits, fish, energy adjusted intake of calcium, vitamin D, vitamin B2, vitamin B6, vitamin B12, and smoking status.