Figure 1. Differences between the mucosally-associated microbiota of Trial and Control subjects, and of Trial subjects over the course of the experiment.

Differences in abundance of mucosally-associated bacteria (at the phylum- I, class – II, order - III and family – IV level) between Trial subjects prior to hookworm infection (T0) and of active coeliac disease Control subjects, based on LDA Effect Size (LEfSe) analysis (A) and paired t-test (B), with differences pre FDR indicated by the respective p-values. (C) Differences in overall taxonomic species richness (left panel) and diversity (right panel) between the mucosally-associated microbiota of Trial subjects prior to hookworm infection (T0) and that of Control subjects with active coeliac disease. Significant differences are indicated with asterisks (*p < 0.05).