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. 2016 Aug 10;41(13):3070–3079. doi: 10.1038/npp.2016.120

Figure 3.

Figure 3

BDNF Val66Met polymorphism impairs BDNF and TrkB expression in mice hippocampus. (a, b) Total hippocampal BDNF mRNA (n=10–11 mice per group) and protein levels (n=12 mice per group) are increased after 28 days of physical exercise and reduced in BDNFMet/Met mice. (c) TrkB protein levels in the hippocampus (HPC) are upregulated by physical exercise. (d) Representative western blot pictures from TrkB and β-actin (n=12 mice per group). Data are expressed as means±SEM. Two-way ANOVA. *P<0.05; **P<0.01; ****P<0.0001. EXE, exercise; SED, sedentary.