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. 2016 Nov 9;7:397. doi: 10.3389/fphar.2016.00397

Figure 2.

Figure 2

(A) Heart to Body weight ratio (H/B) after 4 weeks of CS. Mean Heart to Body weight ratio (H/B) compared to control. CS group had a significantly higher H/B ratio compared to control. H/B ratio was significantly reduced in CS + AO in comparison with CS. Error bars represent SE. One Way Anova test was used to check for significance between the groups. Asterisks indicate statistically significant associations (P < 0.05). (B,C) AO reduces transcriptional expression of fibrotic (ObR and Fn1) markers in rat aortas. Transcriptional expression of (B) ObR and (C) Fn1 were induced in the aortas of CS group. AO reduced the smoking-induced gene expression of ObR and Fn1. Data on each target mRNA was normalized to GAPDH. One Way Anova test was used to check for significance between the groups. Error bars represent SE. Asterisks indicate statistically significant associations (P < 0.05). (D,E) AO reduces protein expression of fibrotic (ObR and Fn1) markers in rat aortas. Protein expression of (D) ObR and (E) Fn1 were induced in the aortas of CS group. Data on each protein was normalized to β-actin. Error bars represent SE. One Way Anova test was used to check for significance between the groups. Asterisks indicate statistically significant associations (P < 0.05).