Table 1.
Pharmacokinetic parameters of talinolol (50 mg dose)
| MZ twin pairs | DZ twin pairs | ||||
|---|---|---|---|---|---|
| Parameter | Unit | Mean ± SD | Median (Min–Max) Ratio Max/Min |
Mean ± SD | Median (Min–Max) Ratio Max/Min |
| Clearance (Cl/F) | l/min | 0.97 ± 0.42 | 0.87 (0.30–2.64) 8.8 |
0.82 ± 0.27 | 0.76 (0.37–1.39) 3.8 |
| Clearance per body weight (Cl/F/kg) | ml/min/kg | 14.4 ± 5.51 | 13.5 (6.16–38.5) 6.3 |
12.1 ± 3.8 | 11.6 (6.96–19.9) 2.9 |
| AUCinfinity | mg*min/l | 62.8 ± 25.2 | 60.2 (22.8–171.1) 7.5 |
71.3 ± 23.8 | 68.6 (37.6–135.8) 3.6 |
| AUC7h | mg*min/l | 20.1 ± 9.10 | 19.3 (7.36–62.7) 8.5 |
24.9 ± 9.93 | 23.6 (11.7–54.8) 4.7 |
| Central volume of distribution (Vz) | l | 1115 ± 510 | 1006 (293–2549) 8.7 |
889 ± 449 | 747 (302–2169) 7.2 |
| Maximum plasma concentration (Cmax) | μg/l | 94.3 ± 47.0 | 84.9 (23.3–258) 11.1 |
124 ± 55.4 | 115 (51.9–269) 5.2 |
| Time of maximum plasma concentration (tmax) | h | 2.6 ± 0.7 | 2.6 (1.2–4.1) 3.4 |
2.6 ± 0.8 | 2.7 (1.0–3.9) 3.9 |
| Terminal elimination half life (t1/2) | h | 13.3 ± 4.0 | 12.2 (7.9–30.0) 3.8 |
11.9 ± 2.7 | 11.5 (7.2–18.1) 4.3 |
MZ monozygotic, DZ dizygotic, SD standard deviation. All pharmacokinetic parameters were calculated with the mean of up to three study days for each subject