Table 2.
Heritability of talinolol clearance (50 mg dose) according to structural equation modeling
| Model | A | D | C | E | Chi2 | p | AIC |
|---|---|---|---|---|---|---|---|
| (95 % CI) | (95 % CI) | (95 % CI) | (95 % CI) | ||||
| Saturated | - | - | - | - | - | - | 63.67 |
| ACE | 0.00 (0.00–0.00) |
- | 0.535 (0.346–0.724) |
0.465 (0.276–0.654) |
36.9 | 0.001 | 70.60 |
| ADE | 0.500 (0.282–0.717) |
0.00 (0.00–0.00) |
- | 0.500 (0.282–0.717) |
39.6 | <0.001 | 73.30 |
| AE | 0.500 (0.282–0.717) |
- | - | 0.500 (0.282–0.717) |
39.6 | <0.001 | 71.30 |
| CE | - | - |
0.535
(0.346–0.724) |
0.465
(0.276–0.654) |
37.9 | 0.002 | 68.60 |
A additive genetic effects, D dominant genetic effects, C common environmental effects, E unique environmental effects, 95 % CI 95 % confidence interval, Chi2 chi-square value, AIC Akaike information criterion. P values were calculated with respect to the saturated model. The best fitting model (CE, bold text) was chosen based on the lowest AIC