Table 3.
Heritability of talinolol pharmacokinetics (50 mg dose) according to the genetic component (rGC)
| Vb | Vw | rGC (95 % CI) | |
|---|---|---|---|
| Cl/F | 0.100 | 0.062 | 0.38 (0.35–0.41) |
| AUC | 476.9 | 225.2 | 0.53 (0.50–0.57) |
| Cmax | 1617 | 1671 | |
| tmax | 0.50 | 0.63 |
rGC genetic component, Cl/F total plasma clearance/bioavailability, AUC area under the curve, C max maximum plasma concentration, t max time of maximum plasma concentration, Vb variance between the subjects, Vw variance within each subject, 95 % CI 95 % confidence interval. The genetic component was calculated as rGC = (Vb − Vw)/Vb as proposed by Kalow [52, 53].