Table 4.
Influence of genetic polymorphisms in genes coding for efflux transporters on talinolol clearance
| Gene | Genetic polymorphism | Variant | Genotype frequency (n) [%] | Clearance [l/min] |
|---|---|---|---|---|
| MDR1 | C1236T | C/C | 31 (34) | 0.77 ± 0.28 |
| rs1128503 | C/T | 47 (52) | 0.96 ± 0.37a | |
| T/T | 21 (24) | 1.11 ± 0.50a | ||
| G2677T/A | G/G | 29 (32) | 0.77 ± 0.29 | |
| (Ala893Ser/Thr) | G/T | 47 (52) | 0.96 ± 0.37b | |
| rs2032582 | T/T | 20 (22) | 1.14 ± 0.50b | |
| G/A | 2 (2) | 0.74 ± 0.03 | ||
| A/A | 0 (-) | - | ||
| T/A | 2 (2) | 0.75 ± 0.10 | ||
| C3435T | C/C | 19 (21) | 0.83 ± 0.28 | |
| rs1045642 | C/T | 62 (68) | 0.97 ± 0.44 | |
| T/T | 19 (21) | 0.92 ± 0.30 | ||
| MDR5 | C392T (Thr131Ile) | C/C | 89 (98) | 0.92 ± 0.37 |
| rs17143212 | C/T | 11 (12) | 1.07 ± 0.54 | |
| T/T | 0 (-) | - | ||
| MRP2 | -C24T | C/C | 73 (80) | 0.92 ± 0.39 |
| rs717620 | C/T | 21 (23) | 1.03 ± 0.41 | |
| T/T | 6 (7) | 0.73 ± 0.33 | ||
| G1249A (Val417Ile) | G/G | 68 (75) | 0.95 ± 0.41 | |
| rs2273697 | G/A | 30 (33) | 0.89 ± 0.37 | |
| A/A | 2 (2) | 0.97 ± 0.05 | ||
| ABCG2 | G34A (Val12Met) | G/G | 96 (105) | 0.94 ± 0.40 |
| rs2231137 | G/A | 4 (5) | 0.84 ± 0.25 | |
| A/A | 0 (-) | - | ||
| C421A (Gln141Lys) | C/C | 75 (82) | 0.94 ± 0.37 | |
| rs2231142 | C/A | 25 (28) | 0.91 ± 0.46 | |
| A/A | 0 (-) | - |
Data are given in mean ± standard deviation. aThere were significant differences between heterozygous (C/T) and homozygous (T/T) carriers of the MDR1 1236 T allele and homozygous carriers of the 1236C allele (C/C) as tested with the Jonckheere–Terpstra test (p = 0.0025). bThere were significant differences between heterozygous (G/T) and homozygous (T/T) carriers of the MDR1 2677 T allele and homozygous carriers of the 2677G allele (G/G) as tested with the Jonckheere–Terpstra test (p = 0.0015). Significance was determined after correction for multiple testing for p < 0.005 (Bonferroni correction)