Table 2.
Minor allele frequency and genotype of the five genotyped SNPs in CYP19A1 and ESR1
| Genotype, n (%) | |||||||
|---|---|---|---|---|---|---|---|
| Gene | SNP | Number assessed | Minor allele frequency | Wild-type | Heterozygous | Homozygous | HWE P value |
| CYP19A1 | rs4646 (G > T) | 1967 | 0.29 | 989 (50) | 822 (42) | 156 (8) | 0.44 |
| CYP19A1 | rs10046 (C > T) | 1967 | 0.48 | 532 (27) | 989 (50) | 446 (23) | 0.75 |
| ESR1 | rs2077647 (A > G) | 1967 | 0.47 | 550 (28) | 999 (51) | 418 (21) | 0.39 |
| ESR1 | rs2234693 (Pvull) (T > C) | 1967 | 0.45 | 594 (30) | 993 (50) | 380 (19) | 0.36 |
| ESR1 | rs9340799 (Xbal) (A > G) | 1967 | 0.36 | 806 (41) | 923 (47) | 238 (12) | 0.30 |
CYP19A1 Cytochrome P450 19A1, ESR1 Estrogen receptor 1, HWE Hardy-Weinberg equilibrium, SNP single nucleotide polymorphism