Table 3.
Peripheral tissue immunolabelling following primary passage of sheep with L-BSE
| Animal ID | Genotype | Clinical status | Survival time (days) | Ganglia | Lymphoid tissues | Muscle | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Trige-minal | Nodose | Cranial cervical | Stellate | Coeliaco-mesenteric | ENS | LRLN | MLN | RAMALT | Spleen | PP | Extra-ocular | ||||
| 457/11 | AFRQ/AFRQ | + | 1236 | + | + | – | – | – | – | – | – | – | – | – | +a |
| 112/12 | + | 1334 | + | + | – | – | – | – | – | – | – | – | – | + | |
| 26/12 | + | 1267 | + | + | – | – | – | – | – | – | – | – | – | + | |
| 98/11 | + | 1186 | + | + | – | nr | – | – | – | – | – | – | – | +a | |
| 1606/10 | + | 867 | – | – | – | – | – | – | – | – | – | – | – | – | |
| 3/11 | ARQ/ARQ | + | 959 | nr | + | – | – | – | – | – | – | – | – | – | + |
| 182/12 | + | 1531 | + | + | – | – | – | – | – | – | – | – | – | +a | |
| 63/11 | + | 956 | nr | + | – | nr | – | – | – | – | – | – | – | + | |
| 455/11 | + | 1186 | + | + | – | – | – | – | – | – | – | – | – | +a | |
| 3/13 | + | 1649 | + | + | – | – | – | – | – | – | – | – | – | +a | |
| 223/13 | ARR/ARR | – | 1998b | – | – | – | – | – | – | – | – | – | – | – | – |
| 224/13 | – | 1999b | nr | nr | – | – | – | – | – | – | – | – | – | – | |
| 10/14 | – | 2005b | – | – | – | – | – | – | – | – | – | – | – | – | |
| 8/14 | – | 2000b | – | – | – | – | – | – | – | – | – | – | – | – | |
| 9/14 | – | 2005b | – | – | – | – | – | – | – | – | – | – | – | – | |
| 4/12 | ARQ/VRQ | + | 1389 | + | – | – | – | – | – | – | – | – | – | – | +a |
| 140/11 | + | 957 | + | + | + | – | – | – | – | – | – | – | – | + | |
| 1591/10 | + | 803 | + | + | – | – | – | – | – | – | nr | – | – | + | |
| 267/11 | + | 1056 | nr | + | inc | inc | – | – | – | – | – | – | – | + | |
| 58/11 | + | 864 | + | + | – | nr | – | – | – | – | – | – | – | +a | |
| 225/13 | VRQ/VRQ | – | 1964b | – | nr | – | – | – | – | – | – | – | – | – | – |
| 113/12 | + | 1337 | + | + | – | – | – | – | – | – | – | – | – | +a | |
| 456/11 | + | 1183 | + | nr | + | – | – | – | – | – | – | – | – | + | |
| 48/13 | – | 1963b | nr | nr | – | inc | + | + | + | + | + | + | + | + | |
| 167/12 | + | 1439 | + | + | – | – | – | – | – | – | – | – | – | + | |
nr: not retrieved; inc: inconclusive, ENS: enteric nervous system, distal ileum, LRLN: lateral retropharyngeal lymph node, MLN: mesenteric lymph node, RAMALT: recto-anal mucosa-associated lymphoid tissue, PP: Peyer’s patches of the distal ileum.
aOccasional positive myocytes in addition to spindle labelling.
bKilled at end of study. No clinical signs.