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. 2016 Oct 18;3(2):e00020. doi: 10.1002/ebm2.20

Table 2.

Study design characteristics to be extracted

Study identifiers

  1. Author

  2. Year of publication

  3. Journal
Animal population

  1. Species

  2. Strain

  3. Comorbidities

  4. Sex

  5. Age
TBI paradigm

  1. Injury model type (weight drop, fluid percussion, controlled cortical injury, projectile concussive impact, penetrating ballistic‐like brain injury, blast‐induced neurotrauma)

  2. Cranium unopened/craniotomy/craniectomy

  3. Location of injury (lobe)

  4. Impactor velocity/peak pressure wave

  5. Baseline neurobehavioural score

  6. Method of animal head stabilization

  7. Anaesthetic agent

  8. Anaesthesia duration
Hypothermia

  1. Target temperature

  2. Duration of hypothermia

  3. Method of hypothermia induction (intra/extracorporeal, permissive)

  4. Delay to treatment

  5. Rate of rewarming

  6. Method of rewarming

  7. Control group temperature 1) normothermia (36.0‐37.9°C for mammals) or 2) hyperthermia (≥38.0°C)

  8. Control group temperature induced or passive
Primary outcome measure

  1. Neurobehavioural outcome score
Secondary outcome measures

  1. Change in contusion size

  2. ICP

  3. Mortality

  4. Biochemical or histological markers: oedema (eg AQP4), axonal damage (e.g. APP), neural cell death