Figure 4.

(a) Representative first-order kinetic plots for the cleavage of N-Trt end groups in HEE-PRX (4.1HEE-PRX) under various pH conditions at 37 °C (open squares: pH 4.0, closed circles: pH 5.0, open triangles: pH 6.0, closed triangles: pH 7.4, open diamonds: pH 8.0). The data are expressed as the mean ± standard deviation (n = 3). (b) Logk-pH profiles for the cleavage of N-Trt end groups in HEE-PRXs at 37 °C (closed squares: 4.1HEE-PRX, open circles: 5.4HEE-PRX, closed triangles: 6.4HEE-PRX, open diamonds: 7.6HEE-PRX).