Figure 9.

mRNA levels of LOX-1, TGF-β1 and CTGF in the groups treated with HFD+FK506 (0.15 mg/kg/day) for 4 weeks, FK506 (0.15 mg/kg/day) for 4 weeks and HFD for 4 weeks. (B) Protein levels of LOX-1 and TGF-β1 in the groups treated with HFD+FK506 (0.15 mg/kg/day) for 4 weeks, FK506 (0.15 mg/kg/day) for 4 weeks, and HFD for 4 weeks. *P<0.01 vs. control group; ^#P<0.05 vs. FK506 or HFD groups (3 independent experiments). HFD, high fat diet; FK506, tacrolimus; LOX-1, lectin-like oxidized low-density lipoprotein receptor-1; TGF-β1, transforming growth factor-β1; CTGF connective tissue growth factor.