Figure 6.

PI3K/AKT/mTOR and ERK1/2 signaling pathways in T/G HA-VSMCs following various treatments. The mRNA expression levels of p-AKT, t-AKT, p-mTOR, t-mTOR, p-ERK and t-ERK were determined by western blotting analysis following treatment with siC, siR, siC + P and siR + P. p-, phosphorylated; t-, total; Akt, protein kinase B; mTOR, mammalian target of rapamycin; ERK, extracellular signal-regulated kinase; si, siRNA; C, control; R, Rab5a; P, PDGF; PDGF, platelet-derived growth factor; T/G HA-VSMC, human aorta-vascular smooth muscle cell line.