Table I.
Comparison of gallbladder SC/ASC and AC clinicopathological features and MCM2 and TIP30 expression status.
| Clinicopathological characteristic | SC (n=46) | ASC (n=80) | χ2 | P-value |
|---|---|---|---|---|
| Sex | ||||
| Male | 19 (41.3) | 26 (32.5) | 0.986 | 0.352 |
| Female | 27 (58.7) | 54 (67.5) | ||
| Age (year) | ||||
| ≤45 | 3 (6.5) | 16 (20.0) | 4.143 | 0.042 |
| >45 | 43 (93.5) | 64 (80.0) | ||
| Differentiation | ||||
| Well-differentiated | 16 (34.8) | 27 (33.8) | ||
| Moderately differentiated | 24 (52.2) | 25 (31.3) | 8.515 | 0.014 |
| Poorly differentiated | 6 (13.0) | 28 (35.0) | ||
| Maximum diameter of tumor (cm) | ||||
| ≤3 cm | 20 (43.5) | 50 (62.5) | 4.280 | 0.039 |
| >3 cm | 26 (56.5) | 30 (37.5) | ||
| Cholecystolithiasis | ||||
| (−) | 18 (39.1) | 42 (52.5) | 2.093 | 0.148 |
| (+) | 28 (60.9) | 38 (47.5) | ||
| TNM stages | ||||
| I+II | 12 (26.1) | 21 (26.3) | ||
| III | 20 (33.5) | 38 (47.5) | 0.287 | 0.866 |
| IV | 14 (30.4) | 21 (26.3) | ||
| Lymph node metastasis | ||||
| (−) | 17 (37.0) | 30 (37.5) | 0.004 | 0.952 |
| (+) | 29 (63.0) | 50 (62.5) | ||
| Locoregional invasion | ||||
| (−) | 16 (34.8) | 31 (38.8) | 0.197 | 0.658 |
| (+) | 30 (62.5) | 49 (61.3) | ||
| Operation methods | ||||
| Radical | 14 (30.4) | 26 (32.5) | ||
| Palliative | 18 (39.1) | 28 (35.0) | 0.215 | 0.898 |
| Without resection | 14 (30.4) | 26 (32.5) | ||
| Mean survival time | 10.07 (4–25) | 10.34 (3–27) | 0.014 | 0.906 |
| MCM2 | ||||
| (−) | 24 (52.2) | 38 (47.5) | 0.951 | 0.382 |
| (+) | 22 (47.8) | 42 (52.5) | ||
| TIP30 | ||||
| (−) | 26 (56.5) | 38 (47.5) | 0.289 | 0.678 |
| (+) | 20 (43.5) | 42 (52.5) |
SC, squamous cell; ASC, adenosquamous carcinoma; MCM2, minichromosome maintenance complex component 2; TIP30, HIV-1 tat interactive protein 2.