Figure 2.

CBD-VEGF alleviated CCl₄-induced liver inflammation and fibrosis. CBD-VEGF was injected to the liver of CCl₄-induced mice. After 4 weeks, the mice were sacrificed. (A) Conventional HE staining (upper panels) and Masson's trichrome staining (lower panels) were performed in liver paraffin sections. Magnification, ×100. (B) Serum ALT and (C) ALB levels were detected. (D) Comparisons of Masson-positive areas in each group. n=5 for each group. Data are presented as the mean ± standard deviation; **P<0.01, *P<0.05. CBD-VEGF, collagen-binding domain-vascular endothelial growth factor; HE, hematoxylin and eosin; ALT, alanine aminotransferase; ALB, albumin; NS, normal saline.