Table 4.
Er-NPCs Injection Did Not Promote the Increase of DA and its Metabolites.
| Right striatum | CTRL | MPTP | MPTP + Er-NPCs |
|---|---|---|---|
| DA | 99.52 ± 11.32 | 48.28 ± 19.50 p < .001 versus CTRL | 36.25 ± 11.07 p < .001 versus CTRL |
| DOPAC | 8.57 ± 1.00 | 4.61 ± 2.36 p < .001 versus CTRL | 3.90 ± 1.06 p < .001 versus CTRL |
| HVA | 15.56 ± 2.02 | 7.68 ± 2.24 p < .001 versus CTRL | 8.28 ± 1.84 p < .001 versus CTRL |
| 3-MT | 7.75 ± 1.18 | 6.71 ± 0.56 | 6.71 ± 2.10 |
| Left striatum | |||
| DA | 99.52 ± 11.30 | 54.44 ± 4.65 p < .001 versus CTRL | 32.32 ± 8.61 p < .001 versus CTRL |
| DOPAC | 8.57 ± 1.00 | 6.09 ± 1.06 p < .001 versus CTRL | 5.27 ± 1.13 p < .001 versus CTRL |
| HVA | 15.56 ± 2.02 | 13.33 ± 3.03 p < .001 versus CTRL | 10.03 ± 2.56 p < .001 versus CTRL |
| 3-MT | 7.75 ± 1.18 | 8.95 ± 1.62 | 6.15 ± 1.93 |
Note. DA = dopamine; DOPAC = 3,4-dihydroxyphenylacetic acid; HVA = homovanillic acid; 3-MT =3-methoxytyramine; CTRL = control; MPTP = 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Er-NPCs = erythropoietin-releasing neural precursors. The determination was performed at 15 days after cells transplantation by HPLC (see Materials and Methods section). Levels of DA, DOPAC, HVA, and 3-MT were determined separately in the left (ipsilateral to the injection) and right (contralateral to the injection site) striatum. Data are expressed in ng/mg of proteins as mean of two experiments ± SD (n = 5 mice in each group).