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. 2016 Sep 1;30(12):4109–4119. doi: 10.1096/fj.201600621R

Figure 3.

Figure 3.

Maximal and sustained contractile force during high-frequency stimulation is reduced in muscles from cOrai-KO mice. A–C) Representative ex vivo specific force traces in Sol muscles from adult WT and cOrai-KO mice stimulated at 1 (A), 20 (B), or 100 Hz (C). Timescale shown in B also applies to panels C, F, and G. Total duration for twitch traces in panels A and E is 250 ms. D) Force-frequency summary for Sol muscles from adult WT and Orai-KO mice (n = 12–13 muscles). E–G) Representative ex vivo specific force traces in EDL muscles from adult WT and cOrai-KO mice stimulated at 1 (E), 20 (F), or 100 Hz (G). H) Force-frequency summary of EDL muscles from adult WT and cOrai-KO mice (n = 14–15 muscles). I) Normalized specific force during repetitive, high-frequency stimulation (1 s tetani, 50 Hz, 0.4 duty cycle) for Sol muscles from adult WT and cOrai-KO mice (n = 6–9 muscles). J) Normalized specific force decay during repetitive, high-frequency stimulation (500 ms, 50 Hz, 0.2 duty cycle) in EDL muscles from WT and cOrai-KO mice (n = 6–10 muscles).