Figure 4.

Loss of Orai1 in skeletal muscle does not alter motor coordination but results in reduction in sustained grip strength and treadmill endurance. A) Motor coordination quantified from average latency to fall from rotarod at indicated speeds in WT and cOrai-KO mice (n = 11–12 animals). B) Sustained grip strength, measured from average latency to fall from inverted grid. Bars represent average latency to fall per trial averaged over 3 d of experiments (n = 8–10 animals). C) Cumulative number of falls during rotarod endurance task in WT and cOrai-KO mice (n = 10–12 animals). D) Summary of average total distance run by WT and Orai-KO mice during 1 h treadmill endurance protocol (n = 7–8 animals).