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NOX2 inhibitor blocks buildup of ROS in CMs and release of IL-1β. A, B) Cytosolic ROS (A) and nuclear/mitochondrial ROS (B) in absence or presence of NOX2 inhibitor in rat CMs exposed to C5a for 1 h at 37°C. C) Companion studies focused on IL-1β release from C5a-activated CMs in the presence or absence of NOX2 inhibitor. CMs exposed to C5a for 8 h. For each bar, n ≥ 4 samples. *P < 0.05.
