Figure 1.

Human serum IGFBP-3, IGF-1, plasma IL-8, and hepatic IL-8 mRNA levels. IGFBP-3 and IGF-1 levels were examined in patients with NAFL and NASH (n = 12 each) and were compared with lean (n = 10) and weight-matched controls (n = 12) with normal liver histology. A, B) Serum IGFBP-3 (A) and IGF-1 (B) decreased progressively from lean normal to obese controls, to patients with NAFL, then to those with NASH (controls vs. NAFL or NASH; P < 0.01). C, D) Circulating IL-8 protein (C) and hepatic IL-8 mRNA (D) were increased in both patients with NAFL and NASH compared with lean and obese controls (P < 0.01). D, E) Circulating IL-8 was directly related to homeostatic model assessment–insulin resistance (HOMA-IR; E), whereas IGFBP-3 was inversely related to HOMA-IR (F). Individual data points or means ± sd are shown.