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. 2016 Sep 14;30(12):4202–4213. doi: 10.1096/fj.201600392RR

Figure 1.

Figure 1.

The expression of Gal3 and NLRP3 inflammasome components are induced in patients with PBC. A) Liver tissues from healthy subjects (Ctrl) and patients with PBC were processed for RT-qPCR to evaluate the expression of Gal3, NLRP3, ASC, and IL-1β. A) The mRNA levels of Gal3, NLRP3, the adaptor ASC and the downstream effector IL-1β were all significantly elevated in livers from patients with PBC. *P < 0.05; means ± sem; n = 4. B) Western blot and densitometry analyses showed that the protein levels of Gal3 and NLRP3 were increased in PBC livers. *P < 0.05; means ± sem; n = 4. C) Immunohistochemistry revealed enhanced signals for Gal3 (a, c) and NLRP3 (b, d) in the livers from patients with PBC compared with normal livers (NL) from healthy control subjects.