Table 4.
Predictive Values of the Liver Stiffness Cutoff of 12 kPa for the Prediction of Liver-Related Events in the Estimation Cohort and in the Validation Cohort
| Estimation Cohort | |||
|---|---|---|---|
| Liver-Related Event | |||
| Liver Stiffness (kPa) | No | Yes | Total |
| <12 | 472 | 8 | 480 |
| ≥12 | 113 | 41 | 154 |
| Total | 585 | 49 | 634 |
| Value | 95% CI | ||
| Sensitivity (%) | 83.7 | 80.8–86.5 | |
| Specificity (%) | 80.7 | 77.6–83.8 | |
| Positive predictive value (%) | 26.6 | 23.2–30.1 | |
| Negative predictive value (%) | 98.3 | 97.3–99.3 | |
| Positive likelihood ratio | 4.33 | 3.52–5.33 | |
| Negative likelihood ratio | 0.20 | 0.11–0.38 | |
| Validation cohort | |||
| Liver-related event | |||
| Liver stiffness (kPa) | No | Yes | Total |
| <12 | 220 | 4 | 224 |
| ≥12 | 77 | 22 | 99 |
| Total | 297 | 26 | 323 |
| Value | 95% CI | ||
| Sensitivity (%) | 84.6 | 80.7–88.6 | |
| Specificity (%) | 74.1 | 69.3–78.8 | |
| Positive predictive value (%) | 22.2 | 17.7–26.8 | |
| Negative predictive value (%) | 98.2 | 96.8–99.7 | |
| Positive likelihood ratio | 3.26 | 2.54–4.20 | |
| Negative likelihood ratio | 0.21 | 0.08–0.51 | |
Abbreviations: CI, confidence interval.