Table 1.
Characteristics of C1 and RTN neuronal responses to sciatic nerve stimulation
| C1 Neurons |
RTN Neurons |
|||||
|---|---|---|---|---|---|---|
| Contralateral stim | Ipsilateral stim | Contralateral stim | Contralateral stim | Ipsilateral stim | Ipsilateral stim | |
| eeCO2, % | 7.6 ± 0.4 | 7.5 ± 0.5 | 4.2 ± 0.1 | 6.8 ± 0.3 | 4.3 ± 0.2 | 7.0 ± 0.3 |
| n cells recorded | 25 | 16 | 19 | 15 | 7 | 6 |
| Baseline frequency, Hz | 6.0 ± 1.1 | 5.8 ± 1.3 | 1.0 ± 0.4 | 6.9 ± 1.4 | 1.0 ± 0.5 | 6.7 ± 2.6 |
| n cells with first peak (%) | 25 (100%) | 16 (100%) | 15 (79%) | 15 (100%) | 5 (71%) | 6 (100%) |
| Onset, ms | 28 ± 5 | 27 ± 6 | 88 ± 30 | 55 ± 14 | 79 ± 63 | 64 ± 26 |
| Duration, ms | 39 ± 4 | 37 ± 4 | 123 ± 36 | 121 ± 42 | 116 ± 52 | 133 ± 46 |
| Maximum time, ms | 44 ± 7 | 38 ± 8 | 122 ± 41 | 85 ± 25 | 121 ± 95 | 93 ± 31 |
| Maximum, Hz | 56 ± 9 | 47 ± 9 | 25 ± 7 | 26 ± 4 | 53 ± 23 | 24 ± 10 |
| Activation, % | 87 ± 16 | 67 ± 13 | 56 ± 12 | 77 ± 27 | 55 ± 26 | 53 ± 19 |
| n cells with second peak (%) | 22 (88%) | 14 (88%) | 6 (32%) | 7 (47%) | 4 (57%) | 4 (67%) |
| Onset, ms | 113 ± 12* | 117 ± 15* | 113 ± 25 | 136 ± 33 | 101 ± 3 | 141 ± 46 |
| Duration, ms | 243 ± 33* | 277 ± 64* | 219 ± 75 | 234 ± 59 | 270 ± 64 | 241 ± 109 |
| Maximum time, ms | 179 ± 13* | 178 ± 34* | 138 ± 23 | 184 ± 36 | 184 ± 45 | 213 ± 93 |
| Maximum, Hz | 49 ± 8 | 48 ± 9 | 46 ± 15 | 32 ± 8 | 40 ± 16 | 27 ± 12 |
| Activation, % | 555 ± 111* | 461 ± 93 | 215 ± 94 | 179 ± 67 | 159 ± 39 | 255 ± 200 |
Percent activation was calculated by subtracting the number of spikes during peak activation from the number of spikes during baseline for the same duration and dividing by the number of sweeps (stimulation). When possible, cells were tested under low and high end-expiratory CO2 (eeCO2) level and with contra- and ipsilateral sciatic stimulation. In certain cases, the first peak has a delayed onset; nevertheless, it was grouped with the first peak data.
*
P < 0.05 vs. peak 1.