Table 3.

Molecules important for oligodendrocyte differentiation and myelination

Cellular Function	Signaling Molecule	Reference
Cell adhesion	Contactin	Hu et al. 2003
Cell adhesion	Integrins	Decker and ffrench-Constant 2004
Cell adhesion	L1-CAM	Stevens et al. 1998
Cell adhesion (extracellular matrix)	Tenascin-C	Frost et al. 1996; Garcion et al. 2001
Growth factor	Insulin-like growth factor (IGF-I)	Carson et al. 1993; Zeger et al. 2007
Growth factor	PDGF-α	Barres and Raff 1993
Growth factor	Epidermal growth factor receptor (EGFR)	Aguirre et al. 2007
Growth factor	FGF	Fumagalli et al. 2011
Growth factor	BDNF	Fulmer et al. 2014; Miyamoto et al. 2015
Receptor tyrosine kinase	Neuregulin 1-ErbB	Brinkmann et al. 2008
Signal transduction	Neurogenic locus notch homolog protein (Notch 1), membrane receptor for Jagged and Delta	Genoud et al. 2002; Wang et al. 1998
Signal transduction	Wnt (Frizzled family receptor, β-catenin translocation to nucleus)	Fancy et al. 2009
G protein-coupled receptor	Gpr 17	Chen et al. 2009
Intercellular signaling	Leucine-rich repeat neuronal protein 1 (LINGO-1)	Aguirre et al. 2007
Thyroid hormone	Thyroxine/triiodothyronine	Barres et al. 1994
Neurotransmitter	ATP/adenosine	Ishibashi et al. 2006; Stevens et al. 2002
Neurotransmitter	GABA	Zonouzi et al. 2015
Neurotransmitter	Glutamate	Lundgaard et al. 2013; Wake et al. 2011, 2015
Neurotransmitter	Acetylcholine	Abiraman et al. 2015; Deshmukh et al. 2013; Mei et al. 2014