Skip to main content
. 2016 Nov 9;11(11):e0165637. doi: 10.1371/journal.pone.0165637

Fig 8. Pronounced effects of potassium channel blocker 4-aminopyridine (4-AP) on “whole” CC CAPs.

Fig 8

(A and B) Superimposed “whole” CC CAPs recorded from CC6 during administration of 0.5 mM 4–AP, shown at two different time scales to illustrate the pronounced prolongation of CAP decay. Note the two visually identifiable slow peaks (peak 2a and peak 2b) at the maximal effect of 4-AP, emerging by gradual changes of peak 2 shape from control to 4-AP. The CAPs were recorded without averaging to reflect the fast changes during the test. (C-E) Time course of changes of CAP area (C) and peak amplitude (D, absolute; E, normalized) during administration of 4-AP. The half-maximum of the effect of 4-AP was reached within 3.5–4 minutes. The effects were reversible (not shown). Room temperature.