Fig. 2.

DyC-OCT quantifies hemodynamics in the retinal vasculature based on measuring tracer content in different compartments. A) Rendering of trilaminar vasculature of the inner retina, showing the optic nerve fiber / ganglion cell layer (ONF/GCL), inner plexiform layer (IPL), and outer plexiform layer (OPL). B) The capillary compartment makes up the bulk of the vascular network with alternating supplying arteries and draining veins radiating from the optic nerve head. C) One approach (Section 2.5.5) to assess microvasculature uses an arterial input (c_a) and the total tracer signal within microvasculature (C_t) to determine the product of plasma flow (PF) and a residue function (R) that describes the fraction of tracer left in microvasculature after an impulsive arterial input. An alternative, but related, approach (Section 2.5.6) uses an arterial input (c_a) and venous output (c_v) to determine the arteriovenous transport function between them (h_av). The mean transit time, defined as the centroid of h_av(t), is marked.