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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Virology. 2016 Sep 12;499:52–64. doi: 10.1016/j.virol.2016.08.036

Table 1.

Mortality, mean death time, mean bird infectious dose, virus shedding, serology and transmission to direct contacts of H5N2 HPAI poultry viruses in 4 week-old chickens.

Virus dose (Log 10 EID50) Mortalitya (MDT) BID50 Virus sheddingb (average titer of positive birds) Serologyc Mortality contactsd (MDT)
1 dpi 2 dpi 3 dpi 4 dpi
OP CL OP CL OP CL OP CL
A/Tk/MN/15 2 0/5 3.6 log10 1/5 (2.1) nd 1/5 (2.0) nd 0/5 nd 1/5 (2.1) nd 0/5 0/3
4 3/5 (2.3) 3/5 (5.2) nd 3/5 (5.9) nd 0/2 nd 1/2 (2.3) nd 0/2 0/3
6 8/8 (2) 10/10 (5.4) 10/10 (4.9) 2/2 (4.2) 2/2 (4.3) - - - - - 2/2 (4)
A/Tk/SD/15 2 0/5 3.2 0/5 nd 0/5 nd 0/5 nd 0/5 nd 0/5 0/3
4 4/5 (4) log10 2/5 (3.9) nd 1/4 (3.3) nd 2/4 (4.0) nd 1/3 (3.2) nd 0/2 0/3
6 7/7 (2.2) 8/10 (3.7) 9/10 (2.9) 2/3 (4.9) 2/3 (3.1) 1/1 (5.1) 1/10 (4.4) - - - 0/2
A/Ck/IA/15 2 1/5 (2) 3.5 log10 1/5 (5.4) nd 1/4 (2.3) nd 1/4 (2.1) nd 1/4 (2.2) nd 0/4 0/3
4 3/5 (3.3) 3/5 (4.8) nd 5/5 (5.9) nd 3/3 (6.1) nd 2/2 (2.0) nd 0/2 0/3
6 8/8 (2.4) 10/10 (4.6) 10/10 (3.5) 5/5 (5.6) 5/5 (4.6) 2/2 (6.1) 2/2 (6.6) - - - 0/2
A/Tk/AR/15 2 0/5 5.1 0/5 nd 0/5 nd 0/5 nd 0/5 nd 0/5 0/3
4 0/5 log10 0/5 nd 0/5 nd 0/5 nd 0/5 nd 0/5 0/3
6 8/9 (2.1) 5/11 (3.8) 5/11 (4.5) 3/5 (4.0) 4/5 (3.4) 0/31 3/3 (2.7) 0/1 0/1 0/1 0/2

EID50, mean egg infectious dose; MDT, mean death time; BID50, mean bird infectious dose; OP, oropharyngeal; CL, cloacal; dpi, days post-inoculation; nd, not done. -, birds dead.

a

# of inoculated birds dead/total # of birds inoculated

b

# of virus-positive birds/total # of birds sampled

c

# of positive birds/total # of birds sampled

d

# of virus-positive birds/total # of birds sampled