Table 4.
Mortality, virus shedding, serology and transmission to direct contacts of H5N2, H5N8, and H5N1 HPAI viruses in mallards.
| Virus | Log 10 Dose | Mortalitya (MDT) | Virus sheddingb (average titer of positive birds) | Serologyc (Log2 titers) | Contacts infectedd | Contacts mortality (MDT) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||||||
| 2 dpi | 4 dpi | 7 dpi | 11 dpi | 14 dpi | |||||||||||
|
| |||||||||||||||
| OP | CL | OP | CL | OP | CL | OP | CL | OP | CL | ||||||
| A/Tk/MN/15 (H5N2) | 2 | 0/5 | 5/5 (5.9) | 5/5 (3.7) | 5/5 (7.6) | 5/5 (5.5) | 5/5 (5.6) | 5/5 (5.3) | 5/5 (4.3) | 5/5 (4.6) | 5/5 (4.1) | 5/5 (4.0) | 5/5 (5.4) | 3/3 | 0/3 |
| 4 | 1/5 (9) | 5/5 (6.6) | 5/5 (5.0) | 5/5 (7.3) | 5/5 (4.8) | 5/5 (4.6) | 5/5 (2.9) | 3/4 (2.9) | 4/4 (3.1) | 3/4 (2.4) | 4/4 (2.9) | 4/4 (5.6) | 3/3 | 0/3 | |
| 6 | 1/8 (9) | 10/10 (7.4) | 10/10 (3.6) | 8/8 (6.8) | 8/8 (4.3) | 8/8 (4.8) | 8/8 (3.2) | 7/7 (2.9) | 7/7 (3.2) | 4/7 (2.6) | 4/7 (2.7) | 7/7 (5.6) | 3/3 | 1/3 (9) | |
| A/Ck/IA/15 (H5N2) | 2 | 0/5 | 1/5 (4.8) | 1/5 (3.3) | 4/5 (3.8) | 2/5 (2.8) | 5/5 (4.8) | 5/5 (2.6) | 1/5 (3.0) | 0/5 | 0/5 | 0/5 | 5/5 (4.6) | 3/3 | 0/3 |
| 4 | 0/5 | 5/5 (4.6) | 0/5 | 5/5 (5.9) | 4/5 (3.6) | 3/5 (3.4) | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 5/5 (6.4) | 3/3 | 0/3 | |
| 6 | 0/8 | 10/10 (4.7) | 3/8 (3.3) | 7/8 (4.9) | 6/8 (3.1) | 1/8 (2.8) | 0/8 | 1/8 (2.7) | 0/8 | 0/8 | 0/8 | 8/8 (5.5) | 3/3 | 0/3 | |
| A/Np/WA/14 (H5N2) | 2 | 0/5 | 2/5 (4.7) | 1/5 (2.9) | 5/5 (4.5) | 4/5 (3.5) | 5/5 (4.2) | 5/5 (3.6) | 5/5 (4.1) | 0/5 | 0/5 | 0/5 | 4/5 (3.2) | 3/3 | 0/3 |
| 4 | 0/5 | 5/5 (5.7) | 5/5 (4.1) | 5/5 (5.6) | 5/5 (4.1) | 5/5 (3.4) | 4/5 (5.0) | 3/5 (2.8) | 4/5 (4.6) | 0/5 | 0/5 | 5/5 (4.4) | 3/3 | 0/3 | |
| 6 | 0/5 | 5/5 (5.5) | 5/5 (3.0) | 5/5 (5.5) | 5/5 (3.5) | 5/5 (3.4) | 5/5 (4.3) | 5/5 (4.2) | 5/5 (3.7) | 0/5 | 0/5 | 5/5 (3.6) | 3/3 | 0/3 | |
| A/Gf/WA/14 (H5N8) | 2 | 0/5 | 4/5 (3.6) | 3/5 (2.7) | 5/5 (6.2) | 5/5 (2.8) | 5/5 (4.3) | 4/5 (2.9) | 2/5 (3.4) | 4/5 (2.5) | 0/5 | 0/5 | 3/5 (3.8) | 3/3 | 0/3 |
| 4 | 0/5 | 5/5 (5.9) | 5/5 (3.1) | 5/5 (5.4) | 5/5 (3.7) | 5/5 (3.3) | 4/5 (3.3) | 3/5 (2.8) | 3/5 (3.0) | 0/5 | 0/5 | 5/5 (4.3) | 3/3 | 0/3 | |
| 6 | 0/5 | 5/5 (5.8) | 5/5 (2.8) | 5/5 (5.2) | 4/5 (3.3) | 5/5 (3.3) | 4/5 (3.1) | 5/5 (2.6) | 2/5 (2.0) | 0/5 | 0/5 | 5/5 (4.2) | 3/3 | 0/3 | |
| A/Ws/Mongolia/05 (H5N1) | 2 | 5/5 (4) | 5/5 (5.5) | 5/5 (3.3) | 2/5 (4.7) | 2/5 (3.0) | - | - | - | - | - | - | - | 3/3 | 3/3 (5) |
| 4 | 5/5 (3.5) | 5/5 (5.6) | 5/5 (3.3) | 2/5 (5.2) | 2/5 (3.2) | - | - | - | - | - | - | - | 3/3 | 3/3 (4.5) | |
| 6 | 5/5 (3.5) | 5/5 (5.5) | 5/5 (3.1) | 2/5 (4.5) | 2/5 (2.8) | - | - | - | - | - | - | - | 3/3 | 3/3 (4.5) | |
EID50, mean egg infectious dose; MDT, mean death time; OP, oropharyngeal; CL, cloacal; dpi, days post-inoculation; na, not applicable.
a
# of inoculated birds dead/total # of birds inoculated
b
# of virus-positive birds/total # of birds sampled
c
# of positive birds/total # of birds sampled
d
# of virus-positive contact birds/total # of contact birds