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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Neurobiol Dis. 2016 Aug 24;96:47–53. doi: 10.1016/j.nbd.2016.08.013

Figure 1.

Figure 1

Locomotor depression induced by the A2AR agonist CGS-21680 (0.03 and 0.1 mg/kg, i.p.) in homozygous (HOM) and heterozygous (HET) Tg51 rats and wild-type littermates WT measured at 3 and 12 months of age. Values represent means ± S.E.M. (n = 6–8 per group) of the average of 10-min period transformed counts (square root) during the 90-min period of observation. * and **: significantly different compared to vehicle-treated rats (VEH); p<0.05 and p<0.01, respectively; Bifactorial ANOVA, followed by one-way ANOVA with Dunnett’s post hoc test.