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Convergence of the free energy change for acetanilide (Panels A & B) and paracetamol (Panels C & D) dual force field simulations are shown. In Panels A & C, the AMOEBA force field is transformed into the OPLS-AA force field in vapor. In Panels B & D, the OPLS-AA force field is transformed into the AMOEBA force field in the crystalline environment.
