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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Addict Biol. 2015 Oct 12;22(2):535–549. doi: 10.1111/adb.12317

Table 2.

Top-20 variants associated with BMI in AD considering EA subjects (A), AA subjects (B), and trans-population analysis (C), respectively. For EAs and trans-population association analysis, we reported also the p value of GIANT consortium (Stage 1). GWS p values are highlighted in bold. Minor allele frequencies (MAF) are calculated for each variant as meta-analysis of the investigated samples

Table 2a – EA association analysis
rsId Chr Location MAF Gene P value (Yale-Penn) P value (SAGE) P value (meta-analysis) Direction P value (GIANT Stage 1)
rs6545444 2 55035355 0.068 EML6 4.13E-04 4.45E-04 7.53E-07 ++ 0.954
rs2116440 2 55037697 0.068 EML6 3.88E-04 4.34E-04 6.90E-07 ++ 0.99
rs200889048 3 74977426 0.063 NA 2.14E-04 2.52E-10 8.98E-12 ++ NA
rs12490016 3 156838931 0.064 LINC00880 1.09E-04 2.16E-05 1.44E-08 ++ NA
rs114337256 4 134164378 0.056 NA 2.33E-06 2.74E-02 3.88E-07 ++ NA
rs1630623 9 75340239 0.177 TMC1 8.66E-04 2.70E-05 1.85E-07 ++ NA
rs9937521 16 53799296 0.396 FTO 7.00E-06 6.01E-03 1.70E-07 −− NA
rs28562191 16 53799303 0.390 FTO 8.44E-06 5.25E-03 1.73E-07 −− NA
rs9937354 16 53799847 0.428 FTO 1.74E-05 9.88E-03 6.65E-07 −− NA
rs9928094 16 53799905 0.428 FTO 1.74E-05 9.88E-03 6.65E-07 −− 1.35E-57
rs9930397 16 53799985 0.428 FTO 1.74E-05 9.88E-03 6.65E-07 −− NA
rs9940278 16 53800200 0.428 FTO 1.74E-05 9.87E-03 6.65E-07 −− NA
rs9939973 16 53800568 0.428 FTO 1.74E-05 9.85E-03 6.63E-07 −− 9.68E-58
rs9940646 16 53800629 0.428 FTO 1.74E-05 9.85E-03 6.63E-07 −− 1.43E-56
rs9940128 16 53800754 0.427 FTO 1.73E-05 9.84E-03 6.58E-07 −− 1.39E-57
rs1421086 16 53801343 0.428 FTO 1.73E-05 9.80E-03 6.57E-07 −− NA
rs9923147 16 53801549 0.427 FTO 1.66E-05 9.75E-03 6.29E-07 −− 1.02E-57
rs1558901 16 53803187 0.429 FTO 1.43E-05 8.16E-03 4.52E-07 −− NA
rs11075985 16 53805207 0.429 FTO 1.46E-05 7.70E-03 4.32E-07 −− 1.60E-57
rs1121980 16 53809247 0.429 FTO 1.36E-05 8.22E-03 4.34E-07 −− 1.78E-57
Table 2b – AA association analysis
rsID Chr Location MAF Gene P value (Yale-Penn) P value (SAGE) P value (meta-analysis) Direction
rs2046823 3 56779011 0.498 ARHGEF3 1.51E-06 2.08E-01 8.53E-07 ++
rs2029466 3 56780003 0.438 ARHGEF3 1.00E-07 6.43E-01 3.52E-07 ++
rs3772218 3 56782813 0.497 ARHGEF3 4.66E-06 1.20E-01 1.40E-06 ++
rs35198830 3 1.74E+08 0.275 NLGN1 9.22E-06 1.27E-02 4.34E-07 ++
rs1436526 4 86977277 0.055 MAPK10 1.03E-05 2.33E-02 7.66E-07 ++
rs73834000 4 86981300 0.055 MAPK10 1.02E-05 2.33E-02 7.54E-07 ++
rs1561154 4 86982434 0.055 MAPK10 1.01E-05 2.33E-02 7.51E-07 ++
rs61454320 9 76530716 0.055 NA 5.51E-06 3.03E-02 4.94E-07 ++
rs73470398 11 31849472 0.147 NA 1.21E-06 6.71E-02 2.16E-07 −−
rs16922496 11 31856488 0.147 NA 1.32E-06 7.08E-02 2.47E-07 −−
rs56950471 11 1.15E+08 0.262 NA 1.14E-05 7.32E-03 3.69E-07 ++
rs74789538 15 36281417 0.086 NA 9.15E-07 1.89E-01 4.75E-07 ++
rs79037607 15 36283130 0.088 NA 1.07E-06 1.50E-01 4.29E-07 ++
rs113423262 15 36291751 0.086 NA 7.97E-07 1.53E-01 3.29E-07 ++
rs116546602 15 36293032 0.086 NA 8.13E-07 1.53E-01 3.38E-07 ++
rs1510391 15 36295848 0.086 NA 8.16E-07 1.61E-01 3.58E-07 ++
rs1584033 18 3240255 0.100 NA 8.45E-07 4.14E-01 1.18E-06 ++
rs1579766 18 3240288 0.099 NA 9.82E-07 4.13E-01 1.35E-06 ++
rs205881 20 486771 0.336 CSNK2A1 5.60E-06 4.19E-02 6.56E-07 −−
rs34379659 22 39575873 0.089 NA 6.00E-07 3.60E-01 7.12E-07 ++
Table 2c – trans-population association analysis
rsId Chr Location MAF (AA/EA) Gene P value (trans-population meta-analysis) Direction P value (EA meta-analysis) P value (AA meta-analysis) P value (GIANT Stage 1)
rs2715093 7 50733034 0.493/0.483 GRB10 1.63E-07 −−−− 6.22E-05 6.96E-04 NA
rs2589626 9 75319272 0.300/0.165 TMC1 1.43E-07 ++++ 4.26E-06 5.00E-03 9.12E-01
rs1630623 9 75340239 0.284/0.177 TMC1 5.14E-09 ++++ 1.85E-07 2.66E-03 NA
rs1444825 9 75345502 0.283/0.166 TMC1 5.73E-08 ++++ 3.40E-06 2.73E-03 8.50E-01
rs1838486 9 75345816 0.281/0.166 TMC1 6.70E-08 ++++ 3.41E-06 3.11E-03 8.49E-01
rs2589608 9 75345891 0.276/0.166 TMC1 2.18E-07 ++++ 3.74E-06 7.68E-03 NA
rs2487465 9 75346270 0.281/0.166 TMC1 6.70E-08 ++++ 3.40E-06 3.11E-03 8.48E-01
rs2487466 9 75346354 0.276/0.166 TMC1 2.17E-07 ++++ 3.73E-06 7.69E-03 NA
rs1444826 9 75346619 0.281/0.166 TMC1 6.70E-08 ++++ 3.40E-06 3.12E-03 8.39E-01
rs1444827 9 75346847 0.291/0.162 TMC1 1.05E-07 ++++ 9.20E-06 2.24E-03 8.28E-01
rs2589610 9 75347643 0.282/0.167 TMC1 5.43E-08 ++++ 2.34E-06 3.38E-03 7.64E-01
rs1663738 9 75347852 0.281/0.166 TMC1 6.84E-08 ++++ 3.41E-06 3.16E-03 7.50E-01
rs10655647 9 75348082 0.276/0.166 TMC1 1.87E-07 ++++ 3.09E-06 7.70E-03 NA
rs2589632 9 75349586 0.283/0.166 TMC1 1.39E-07 ++++ 3.39E-06 5.70E-03 5.92E-01
rs2793168 9 75350343 0.282/0.166 TMC1 7.11E-08 ++++ 3.42E-06 3.26E-03 6.40E-01
rs2793169 9 75354006 0.284/0.166 TMC1 1.36E-07 ++++ 3.58E-06 5.41E-03 NA
rs2793170 9 75355918 0.282/0.166 TMC1 8.48E-08 ++++ 3.59E-06 3.66E-03 NA
rs2793171 9 75357642 0.282/0.166 TMC1 8.07E-08 ++++ 3.19E-06 3.80E-03 NA
rs2793172 9 75357660 0.291/0.166 TMC1 9.65E-08 ++++ 3.20E-06 4.40E-03 6.65E-01
rs1361531 9 75360357 0.282/0.166 TMC1 1.01E-07 ++++ 3.27E-06 4.48E-03 6.46E-01