Table 2.
Top-20 variants associated with BMI in AD considering EA subjects (A), AA subjects (B), and trans-population analysis (C), respectively. For EAs and trans-population association analysis, we reported also the p value of GIANT consortium (Stage 1). GWS p values are highlighted in bold. Minor allele frequencies (MAF) are calculated for each variant as meta-analysis of the investigated samples
| Table 2a – EA association analysis | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| rsId | Chr | Location | MAF | Gene | P value (Yale-Penn) | P value (SAGE) | P value (meta-analysis) | Direction | P value (GIANT Stage 1) |
| rs6545444 | 2 | 55035355 | 0.068 | EML6 | 4.13E-04 | 4.45E-04 | 7.53E-07 | ++ | 0.954 |
| rs2116440 | 2 | 55037697 | 0.068 | EML6 | 3.88E-04 | 4.34E-04 | 6.90E-07 | ++ | 0.99 |
| rs200889048 | 3 | 74977426 | 0.063 | NA | 2.14E-04 | 2.52E-10 | 8.98E-12 | ++ | NA |
| rs12490016 | 3 | 156838931 | 0.064 | LINC00880 | 1.09E-04 | 2.16E-05 | 1.44E-08 | ++ | NA |
| rs114337256 | 4 | 134164378 | 0.056 | NA | 2.33E-06 | 2.74E-02 | 3.88E-07 | ++ | NA |
| rs1630623 | 9 | 75340239 | 0.177 | TMC1 | 8.66E-04 | 2.70E-05 | 1.85E-07 | ++ | NA |
| rs9937521 | 16 | 53799296 | 0.396 | FTO | 7.00E-06 | 6.01E-03 | 1.70E-07 | −− | NA |
| rs28562191 | 16 | 53799303 | 0.390 | FTO | 8.44E-06 | 5.25E-03 | 1.73E-07 | −− | NA |
| rs9937354 | 16 | 53799847 | 0.428 | FTO | 1.74E-05 | 9.88E-03 | 6.65E-07 | −− | NA |
| rs9928094 | 16 | 53799905 | 0.428 | FTO | 1.74E-05 | 9.88E-03 | 6.65E-07 | −− | 1.35E-57 |
| rs9930397 | 16 | 53799985 | 0.428 | FTO | 1.74E-05 | 9.88E-03 | 6.65E-07 | −− | NA |
| rs9940278 | 16 | 53800200 | 0.428 | FTO | 1.74E-05 | 9.87E-03 | 6.65E-07 | −− | NA |
| rs9939973 | 16 | 53800568 | 0.428 | FTO | 1.74E-05 | 9.85E-03 | 6.63E-07 | −− | 9.68E-58 |
| rs9940646 | 16 | 53800629 | 0.428 | FTO | 1.74E-05 | 9.85E-03 | 6.63E-07 | −− | 1.43E-56 |
| rs9940128 | 16 | 53800754 | 0.427 | FTO | 1.73E-05 | 9.84E-03 | 6.58E-07 | −− | 1.39E-57 |
| rs1421086 | 16 | 53801343 | 0.428 | FTO | 1.73E-05 | 9.80E-03 | 6.57E-07 | −− | NA |
| rs9923147 | 16 | 53801549 | 0.427 | FTO | 1.66E-05 | 9.75E-03 | 6.29E-07 | −− | 1.02E-57 |
| rs1558901 | 16 | 53803187 | 0.429 | FTO | 1.43E-05 | 8.16E-03 | 4.52E-07 | −− | NA |
| rs11075985 | 16 | 53805207 | 0.429 | FTO | 1.46E-05 | 7.70E-03 | 4.32E-07 | −− | 1.60E-57 |
| rs1121980 | 16 | 53809247 | 0.429 | FTO | 1.36E-05 | 8.22E-03 | 4.34E-07 | −− | 1.78E-57 |
| Table 2b – AA association analysis | ||||||||
|---|---|---|---|---|---|---|---|---|
| rsID | Chr | Location | MAF | Gene | P value (Yale-Penn) | P value (SAGE) | P value (meta-analysis) | Direction |
| rs2046823 | 3 | 56779011 | 0.498 | ARHGEF3 | 1.51E-06 | 2.08E-01 | 8.53E-07 | ++ |
| rs2029466 | 3 | 56780003 | 0.438 | ARHGEF3 | 1.00E-07 | 6.43E-01 | 3.52E-07 | ++ |
| rs3772218 | 3 | 56782813 | 0.497 | ARHGEF3 | 4.66E-06 | 1.20E-01 | 1.40E-06 | ++ |
| rs35198830 | 3 | 1.74E+08 | 0.275 | NLGN1 | 9.22E-06 | 1.27E-02 | 4.34E-07 | ++ |
| rs1436526 | 4 | 86977277 | 0.055 | MAPK10 | 1.03E-05 | 2.33E-02 | 7.66E-07 | ++ |
| rs73834000 | 4 | 86981300 | 0.055 | MAPK10 | 1.02E-05 | 2.33E-02 | 7.54E-07 | ++ |
| rs1561154 | 4 | 86982434 | 0.055 | MAPK10 | 1.01E-05 | 2.33E-02 | 7.51E-07 | ++ |
| rs61454320 | 9 | 76530716 | 0.055 | NA | 5.51E-06 | 3.03E-02 | 4.94E-07 | ++ |
| rs73470398 | 11 | 31849472 | 0.147 | NA | 1.21E-06 | 6.71E-02 | 2.16E-07 | −− |
| rs16922496 | 11 | 31856488 | 0.147 | NA | 1.32E-06 | 7.08E-02 | 2.47E-07 | −− |
| rs56950471 | 11 | 1.15E+08 | 0.262 | NA | 1.14E-05 | 7.32E-03 | 3.69E-07 | ++ |
| rs74789538 | 15 | 36281417 | 0.086 | NA | 9.15E-07 | 1.89E-01 | 4.75E-07 | ++ |
| rs79037607 | 15 | 36283130 | 0.088 | NA | 1.07E-06 | 1.50E-01 | 4.29E-07 | ++ |
| rs113423262 | 15 | 36291751 | 0.086 | NA | 7.97E-07 | 1.53E-01 | 3.29E-07 | ++ |
| rs116546602 | 15 | 36293032 | 0.086 | NA | 8.13E-07 | 1.53E-01 | 3.38E-07 | ++ |
| rs1510391 | 15 | 36295848 | 0.086 | NA | 8.16E-07 | 1.61E-01 | 3.58E-07 | ++ |
| rs1584033 | 18 | 3240255 | 0.100 | NA | 8.45E-07 | 4.14E-01 | 1.18E-06 | ++ |
| rs1579766 | 18 | 3240288 | 0.099 | NA | 9.82E-07 | 4.13E-01 | 1.35E-06 | ++ |
| rs205881 | 20 | 486771 | 0.336 | CSNK2A1 | 5.60E-06 | 4.19E-02 | 6.56E-07 | −− |
| rs34379659 | 22 | 39575873 | 0.089 | NA | 6.00E-07 | 3.60E-01 | 7.12E-07 | ++ |
| Table 2c – trans-population association analysis | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| rsId | Chr | Location | MAF (AA/EA) | Gene | P value (trans-population meta-analysis) | Direction | P value (EA meta-analysis) | P value (AA meta-analysis) | P value (GIANT Stage 1) |
| rs2715093 | 7 | 50733034 | 0.493/0.483 | GRB10 | 1.63E-07 | −−−− | 6.22E-05 | 6.96E-04 | NA |
| rs2589626 | 9 | 75319272 | 0.300/0.165 | TMC1 | 1.43E-07 | ++++ | 4.26E-06 | 5.00E-03 | 9.12E-01 |
| rs1630623 | 9 | 75340239 | 0.284/0.177 | TMC1 | 5.14E-09 | ++++ | 1.85E-07 | 2.66E-03 | NA |
| rs1444825 | 9 | 75345502 | 0.283/0.166 | TMC1 | 5.73E-08 | ++++ | 3.40E-06 | 2.73E-03 | 8.50E-01 |
| rs1838486 | 9 | 75345816 | 0.281/0.166 | TMC1 | 6.70E-08 | ++++ | 3.41E-06 | 3.11E-03 | 8.49E-01 |
| rs2589608 | 9 | 75345891 | 0.276/0.166 | TMC1 | 2.18E-07 | ++++ | 3.74E-06 | 7.68E-03 | NA |
| rs2487465 | 9 | 75346270 | 0.281/0.166 | TMC1 | 6.70E-08 | ++++ | 3.40E-06 | 3.11E-03 | 8.48E-01 |
| rs2487466 | 9 | 75346354 | 0.276/0.166 | TMC1 | 2.17E-07 | ++++ | 3.73E-06 | 7.69E-03 | NA |
| rs1444826 | 9 | 75346619 | 0.281/0.166 | TMC1 | 6.70E-08 | ++++ | 3.40E-06 | 3.12E-03 | 8.39E-01 |
| rs1444827 | 9 | 75346847 | 0.291/0.162 | TMC1 | 1.05E-07 | ++++ | 9.20E-06 | 2.24E-03 | 8.28E-01 |
| rs2589610 | 9 | 75347643 | 0.282/0.167 | TMC1 | 5.43E-08 | ++++ | 2.34E-06 | 3.38E-03 | 7.64E-01 |
| rs1663738 | 9 | 75347852 | 0.281/0.166 | TMC1 | 6.84E-08 | ++++ | 3.41E-06 | 3.16E-03 | 7.50E-01 |
| rs10655647 | 9 | 75348082 | 0.276/0.166 | TMC1 | 1.87E-07 | ++++ | 3.09E-06 | 7.70E-03 | NA |
| rs2589632 | 9 | 75349586 | 0.283/0.166 | TMC1 | 1.39E-07 | ++++ | 3.39E-06 | 5.70E-03 | 5.92E-01 |
| rs2793168 | 9 | 75350343 | 0.282/0.166 | TMC1 | 7.11E-08 | ++++ | 3.42E-06 | 3.26E-03 | 6.40E-01 |
| rs2793169 | 9 | 75354006 | 0.284/0.166 | TMC1 | 1.36E-07 | ++++ | 3.58E-06 | 5.41E-03 | NA |
| rs2793170 | 9 | 75355918 | 0.282/0.166 | TMC1 | 8.48E-08 | ++++ | 3.59E-06 | 3.66E-03 | NA |
| rs2793171 | 9 | 75357642 | 0.282/0.166 | TMC1 | 8.07E-08 | ++++ | 3.19E-06 | 3.80E-03 | NA |
| rs2793172 | 9 | 75357660 | 0.291/0.166 | TMC1 | 9.65E-08 | ++++ | 3.20E-06 | 4.40E-03 | 6.65E-01 |
| rs1361531 | 9 | 75360357 | 0.282/0.166 | TMC1 | 1.01E-07 | ++++ | 3.27E-06 | 4.48E-03 | 6.46E-01 |