. Author manuscript; available in PMC: 2016 Nov 9.

Published in final edited form as: Eur J Med Chem. 2011 May 23;46(9):3721–3733. doi: 10.1016/j.ejmech.2011.05.038

Table 2.

MTII/h-MC4Ra interactions.

Residue^a	Surrounding residue
Nle⁴	Val193 (TM5), His264^b (TM6), Leu265 (TM6), Tyr268 (TM6)
Asp⁵
His⁶	Asp122 (TM3), Asn123(TM3), Asp126 (TM3)
DPhe⁷	Asp126 (TM3), Ile129 (TM3), Leu133 (TM3), Phe184 (TM4), Phe261 (TM6), Phe284 (TM7), Leu288 (TM7)
Arg⁸	Glu100 (TM2), Asp122 (TM3), Ile125 (TM3), Asp126 (TM3), Ile129(TM3)
Trp⁹	His264 (TM6), Phe267 (TM6), Pro272 (EL3), Val278 (EL3), Phe280 (EL3), Phe284 (TM7)
Lys¹⁰	Tyr276 (EL3), Val278 (EL3), Met281 (EL3)

For sake of clarity, the residue numbers of the ligands are reported as superscript while those of the receptor are not.

Receptor residues involved in mutagenesis studies are shown in bold.