Table 1. Diagnostic Sensitivities and Specificities of Visual Rating of Cortical Atrophy.
| Study Subjects | Sensitivity | Specificity | |
|---|---|---|---|
| Diffuse cortical atrophy | |||
| Global cortical atrophy scale | NA | NA | NA |
| Ventricular enlargement scale (26) | AD or DLB vs. controls | 94% | 40% |
| Medial temporal lobe atrophy | |||
| Scheltens et al. (29) | AD | 81% | NA |
| Duara et al. (34) | Probable AD vs. controls | 85% | 82% |
| Modified MTA rating on axial scan (36) | AD vs. controls | 76% | 80% |
| Posterior cortical atrophy | |||
| Koedam scale (42) | AD vs. controls | 58% | 95% |
| Combined Scheltens + Koedam scale (42) | AD vs. controls | 73% | 87% |
| Frontotemporal lobar atrophy | |||
| FTLA scale (46) | Semantic dementia | 100% | NA |
| FTLA scale (46) | Behavioral variant frontotemporal dementia | 53% | NA |
AD = Alzheimer's disease, DLB = dementia with Lewy bodies, FTLA = frontotemporal lobar atrophy, MTA = medial temporal lobe atrophy, NA = not applicable