Table 4. Suggested Imaging Protocols for Cognitively Impaired Patients in Clinical Practice and for Academic Research.

Protocol for Clinical Practice	Protocol for Research Purpose*
3D T1-weighted images (MPRAGE)	3D (sagittal) T1-weighted images (MPRAGE)
- Parallel imaging factor = 2	- Parallel imaging factor = 2
- ≤ 1.2 × 1.2 × 1.2 mm, 256 mm FOV	- ≤ 1.2 × 1.2 × 1.2 mm, 256 mm FOV
2D FLAIR	3D (sagittal) FLAIR
	- 1 × 1 × 1 mm, 256 mm FOV
2D GRE (or SWI)	2D (axial) GRE or 3D (axial) SWI
	- 3 mm slice thickness
Optional: 2D T2WI, DWI, or MRA	Resting state fMRI
	- TR = 2000 ms
	Diffusion tensor imaging (30 directions or more)
	Optional: arterial spin labeling (ASL)

^*Adapted from Korea-ADNI MR protocol. DWI = diffusion weighted imaging, FLAIR = fluid-attenuated inversion recovery, fMRI = functional magnetic resonance imaging, FOV = field of view, GRE = gradient recalled echo, MPRAGE = magnetization-prepared rapid gradient-echo, MRA = magnetic resonance angiography, SWI = susceptibility-weighted imaging, T2WI = T2-weighted imaging, 2D = twodimensional, 3D = three-dimensional