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. 2016 Nov 1;111(9):1897–1907. doi: 10.1016/j.bpj.2016.09.020

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© 2016 Biophysical Society.

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Enhancement and inhibition of hexameric Orai1 concatemers by 2-APB. (A) 5 μM 2-APB enhances steady-state Ca²⁺ current through 1xOrai1 (left) or 6xOrai1 channels (right). Currents are from two cells at −100 mV in 20 mM Ca²⁺_o. (B) A higher dose of 2-APB (50 μM) transiently enhances and stably inhibits currents through 1xOrai1 (left) and 6xOrai1 channels (right). 100 μM La³⁺ was added as indicated to fully block current. (C) Summary of the effects of 2-APB. Enhancement and inhibition of current are normalized to the current magnitude immediately before application of the drug. Averages are mean ± SE, n = 4–7 cells.