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. 2016 Nov 1;111(9):1897–1907. doi: 10.1016/j.bpj.2016.09.020

Table 1.

Unitary Properties of Native CRAC Channels and Channels Derived from 1xOrai1 or 6xOrai1

Channel Po iNa (fA) Ca2+ Affinity (K1/2, μM) nH n
Native CRACa 0.79 ± 0.02 −90.9a 19.6 1.2 3–10
1xOrai1b 0.81 ± 0.04 −89.5 ± 1.5 16.4 ± 1.2 1.33 ± 0.08 3
6xOrai1b 0.76 ± 0.04 −86.9 ± 7.0 15.9 ± 2.7 1.15 ± 0.02 4

Values are mean ± SE. For all properties, p > 0.05 between 1xOrai1 and 6xOrai1 using a two-tailed t-test.

a

Data from Jurkat cell ICRAC measured at −110 mV, taken from Prakriya and Lewis (26). The iNa value here is extrapolated to a potential of −100 mV using the Na+-ICRAC I/V relation.

b

1xOrai1 and 6xOrai1 channel properties measured at −100 mV.