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. 2016 Nov 9;1(6):e00288-16. doi: 10.1128/mSphere.00288-16

FIG 7 .

FIG 7 

Potential intramolecular interactions of Nef W13 and A84. Structural model of HIV-1 Nef (PDB ID 4EN2). (A) The N-terminal alpha helix of HIV-1 Nef depicted as a cartoon structure in green with the side chain of W13 in orange. The remaining Nef structure is shown by surface representation with electrostatic potentials in red (negative charge) and blue (positive charge). Zoomed-in images showing W13 (top right) and mutant W13R (bottom right) are also shown. (B) Nef alpha helix 2 depicted as a cartoon structure in green with the side chain of A84 in orange. The remaining Nef structure is shown by surface representation with electrostatic potentials in red (negative charge) and blue (positive charge). Zoomed-in images showing A84 (top right) and mutant A84V (bottom right) are also shown. (C) Amino acid sequence of NL4.3 Nef with the N-terminal alpha helix and alpha helix 2 depicted with the colors described in panels A and B.