Table 3.

Odds ratios for swollen or tender joints at sites typical for RA^* stratified by age and cumulative smoking at baseline (n=962).

Stratum	Covariates	Outcomes/Total N	OR (95% CI)
Age <50 years	Never smoker	44/362	1.0 (Ref)
	>0 to ≤10 pack-years	34/151	2.10 (1.28–3.45)
	>10 pack-years	17/45	4.39 (2.23–8.66)
Age ≥50 years	Never smoker	51/180	1.0 (Ref)
	>0 to ≤10 pack-years	31/98	1.17 (0.69–2.00)
	>10 pack-years	43/126	1.31 (0.80–2.14)
Never smoker	Age <50 years	44/362	1.0 (Ref)
	Age ≥50 years	51/180	2.86 (1.82–4.49)
>0 to ≤10 pack-years	Age <50 years	34/151	1.0 (Ref)
	Age ≥50 years	31/98	1.59 (0.90–2.82)
>10 pack-years	Age <50 years	17/45	1.0 (Ref)
	Age ≥50 years	43/126	0.85 (0.42–1.73)

^*RA-specific joints considered were metacarpophalangeal joints, proximal interphalangeal joints, wrists, elbows, and metatarsophalangeal joints. First metacarpophalangeal or metatarsophalangeal joints as well as swollen joints deemed to be due to trauma or degenerative disease were not included.

Four subjects did not have data on cumulative smoking at baseline.

CI, confidence interval; OR, odds ratio; RA, rheumatoid arthritis.

Bolding indicates p<0.05.