Skip to main content
. 2016 Nov 10;6:36746. doi: 10.1038/srep36746

Figure 7. The schematic model for mechanism involved in high glucose-induced BACE1 expression and amyloidogenesis of SK-N-MC.

Figure 7

High glucose stimulates ROS production, leads to increase of HIF-1α for nuclear translocation and phosphorylation of JNK. Translocated HIF-1α is bound to HRE promoter region of bace1 gene, subsequently increases BACE1 expression. Phosphorylated JNK stimulates decrease in LXRα expression, reduced binding LXRα to the LXE promoter region of abca1 gene, leads to reduction of ABCA1 expression and intracellular cholesterol accumulation which may be involved in high glucose-induced lipid raft reorganization. In addition, high glucose-lipid raft modification induces BACE1 expression on the lipid raft, stimulates to Aβ secretion in SK-N-MC.