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. 2016 Nov 10;6:36552. doi: 10.1038/srep36552

Figure 1. Epac1 knockdown alleviates neointima formation in carotid arteries after ligation in vivo.

Figure 1

Left side carotid artery from WT (N = 7) and Epac1−/− mice (N = 7) were ligated and analyzed at day 28 after ligation. Luminal obliteration was significantly reduced in the carotid artery from Epac1−/− mice compared to WT mice. (A) H&E stained cross sections of contralateral unligated and ligated carotid arteries in WT and Epac1−/− mice. Black lines indicate inner and outer elastic lamina. Quantification of neointima area (B) and neointima/media ratio (C) of injured carotid arteries from WT and Epac1−/− mice. The lumen inside the external elastic lamina (EEL) was significantly larger in the Epac1−/− group (D) while the luminal obliteration, defined as percentage of the neointima taking up the internal elastic lamina, was significantly reduced in the Epac1 null mice. (E) Data are expressed as mean ± SEM. N = 7 from pooled male and female samples. *P < 0.05, **P < 0.01.