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. 2016 Nov 10;6:36530. doi: 10.1038/srep36530

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Copyright © 2016, The Author(s)

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Scale bars: 50 μm.In control group(C), no evident histological changes were observed. In LPS group(L), LPS + NaHCO3 group(LNaHCO3) and LPS + NaOH group (LNaOH), there were notable inflammatory cell infiltration, interalveolar septal thickening and hemorrhaging. In LPS + Hemin group(LH), the pathological injury in the lung tissues was ameliorated. By contrast, in LPS + ZnPP-IX group(LZ), the histological injury in lung tissues became more severe. However, in Hemin group(H), ZnPP-IX group(Z) and Hemin + ZnPP-IX group(HZ), the pathological changes showed no evident differences from those in control group(C).