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. 2016 Nov 10;6:36530. doi: 10.1038/srep36530

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(A) Shows mRNA expression of HO-1. (B) Shows mRNA expression of Mfn1. Compared with control group(C), expression of Mfn1 was decreased, but expression of HO-1 was increased in LPS group(L), LPS + NaHCO3 group(LNaHCO3) and LPS + NaOH group (LNaOH)(P < 0.05). Compared with LPS group(L), mRNA expression of Mfn1 was significantly increased, and HO-1 expression was increased in LPS + Hemin group(LH) (P < 0.05). However, compared with LPS group(L), mRNA expression of Mfn1 and HO-1 were decreased in LPS + ZnPP-IX group(LZ) (P < 0.05). After using both Hemin and Znpp-IX, mRNA expression of Mfn1 in LPS + Hemin + ZnPP-IX group(LHZ) was similar to LPS group(L) (P < 0.05). *p < 0.05 versus control group(C); ^#p < 0.05 versus LPS group(L).