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. 2016 Nov 10;6:36787. doi: 10.1038/srep36787

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The Ca²⁺ influx across transmembrane pores created by SLY, the cholesterol-dependent cytolysin (CDC) of S. suis, triggers the Ca²⁺-MLCK and the “outside-in” signalling, leading to α-granules (P-selectin) release to the platelets surface. Subsequently, P-selectin mediates the platelet adhesion to neutrophils to form PNC.