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. 2016 Nov 10;6:36804. doi: 10.1038/srep36804

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Experimental groups used to identify sleep and wake genes. (b) Left panel, functional characterization of genes differentially expressed in wake (W + EW > S) and sleep (S > W + EW). A total of 392 unique genes for W + EW and 469 unique genes for S were identified and mapped for functional annotation analysis (DAVID default settings, except for the final group = 5 and multiple linkage threshold = 0.75). Top 10 functional annotation clusters in order of enrichment score are shown for W + EW and S. Right, heat diagram shows the probe set intensity of the DNA repair cluster for each individual S, W, and EW mouse.