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Evolutionary relationships among mammalian Frizzled proteins and genes. (A) Dendrogram showing the relatedness of the 10 mammalian Frizzled amino acid sequences. (B) Intron–exon structures of mammalian Frizzled genes, with coding regions depicted schematically as the same length. Only Fz3, Fz4, and Fz6 have introns within the coding region. The five coding introns in the Fz3 and Fz6 genes are located at identical positions. From Hua, Chang, Wang, Smallwood, and Nathans (2014).
