Figure 2.

Network map of LC3B and its interacting-proteins with GO categories. (A) There are approximately 500 candidate interacting proteins for LC3B. One-third of the interacting proteins are associated with nuclear components and pathways. The interaction data are from Behrends and colleagues,⁴⁹ and BioGRID (thebiogrid.org). The program of Cytoscape (version 3.2.1)⁷⁰ is used to visualize and analyze the interaction network. Gene relationships are obtained from BioGrid (version 3.2)⁷¹ and input into Cytoscape with undirected connection. Finally, the network is displayed using force-directed layout algorithms. Red dot, LC3B; orange dots, proteins involved in the nucleus and nuclear related activities; blue dots, other interacting proteins. (B) GO categories of LC3B interacting-proteins involved in the nucleus and nuclear related activities. The subsets of gene ontology terms for LC3B and interacting-proteins are analyzed according to the DAVID program.⁷² Top 20 categories with interacting-protein numbers are listed.